Did anyone take Zofran and have it not work or make them sicker when it wore off?

Hey Ladies, I have a question.

I was SOOOO sick during my entire pregnancy with ds. I threw up every single day and was just nauseous all the time. However, I wasn't really throwing up too much food ( sorry) more like just some food, fluids, and A LOT of just heaving. I refused to take the Zofran my OB prescribed b/c I was just nervous it would do something to the baby. In retrospect I thought that was kind of silly since I was also pretty free with Zantac the whole time, lol. I don't know what got into my head that Zofran would cause a terrible deformity but a million Zantacs would be okie dokie but my crazy brain is another post I guess...

Anyway, I have a new OB this time and he prescribed it again and told me to just fill it and have it. The night before last I was sooo sick I finally took it but then I couldn't hold back and I'm pretty sure I vomited it up and then I just fell asleep. I tend to get very sick in the afternoon and stay that way all evening, so yesterday I thought I would try and take the 4mg of Zofran in the morning- I thought that way I could sort of try it out without risking throwing it back up again.

I felt pretty okay during the early day but honestly I often have some decent time usually around those hours so I wasn't sure if it was the Zofran or not. THEN around 3pm I started getting SO SO SICK. I was ALL FREAKING NIGHT. I can't help but wonder if it was some kind of rebound effect from the medicine or what.

On top of that today I read some girl's story on another board saying that she had 2 missed mcs and each dated the fetus' demise the same day as she took Zofran. I know it's most likely coincidental but of course now I am so paranoid- especially after I got so sick last night.

Thanks for reading if you got this far and any experiences are appreciated.

Re: Did anyone take Zofran and have it not work or make them sicker when it wore off?

I took Zofran... it helped, especially when I took it at night so I wouldn't wake up nauseous. I tried to limit my Zofran to 1-2x per day since I found it caused terrible constipation, so one problem became another.

Maybe it's naive, but I trust that my doctor wouldn't give me anything I couldn't take. He wouldn't even allow me to use ear drops for itchy ears, so if he allowed Zofran, I figured it was okay!

Good luck and I hope you feel better!

Re: Did anyone take Zofran and have it not work or make them sicker when it wore off?

I've been on Zofran since the beginning of my pregnancy. I'm almost 14 weeks now and had complications with it. When I was on 4mg. of Zofran it didn't work for me either, so my doctor upped the dosage to 8mg twice a day and it worked wonders. I only needed to take it once a day and now maybe once a week. I hope you feel better soon and get some relief.

Re: Did anyone take Zofran and have it not work or make them sicker when it wore off?

maybe you have a virus?

I was put on it last week because I had a terrible virus, and I was still throwing up with it. its not supposed to stop that, just make you feel less queasy, for me it did, but it didn't make it go away.

I would call the dr if you are still so sick in a few days

I know there is a bad condition you can have with pregnancy and extremly bad m/s that 1% of pregnant women get that's not you!

Re: Did anyone take Zofran and have it not work or make them sicker when it wore off?

Zofran helped me, but when it wore off, I had a "hangover" from it with a bad headache and dizziness! I only would take it if I was going to be asleep when it wore off, other than that, I just suffered through it!

Re: Did anyone take Zofran and have it not work or make them sicker when it wore off?

Didn't work for me. I got the sublinguals that disolve under your tounge and within about an hours I was projectile vomiting and dizzy. I thought it was a fluke and tried again. The same thing happened. I was put on Phenergan and was on that my whole pregnancy with Emmy due to severe hyperemesis. It never really went away and while the Phenergan helped, I was still always nauseaus just not vomiting. I can assure you it's not just you that found Zofran to be worse then the actual vomiting

Re: Did anyone take Zofran and have it not work or make them sicker when it wore off?

I have been taking it for the past 2 and a half weeks. It has changed my world. I feel slightly functional. Since the first few days I have not thrown up within the 8 hour window that it lasts for. I'm currently in the 8 hour window and nauseous as all hell, but not actively vomiting.
I also go to bed with a headache every night. The pros for me out weighed the cons.

I only agreed to take it after my OB said she took it for her first and third pregnancies.

Good Luck

Message edited 4/20/2011 1:42:07 PM.

Re: Did anyone take Zofran and have it not work or make them sicker when it wore off?

I took it and it didn't help me, so I stopped. The side effects stink.

Re: Did anyone take Zofran and have it not work or make them sicker when it wore off?

I took it for a very short period of time because it either gave me a headache or caused me to be sleepy. It did not help my nausea/vomiting. So I just dealt with the severe nausea and vomiting until wk 22. When I googled zofran I didn't find any significant studies in regards to defects or birth complications. HTH

Re: Did anyone take Zofran and have it not work or make them sicker when it wore off?

I tried it but got horrible migraines and constipation. It didn't stop the feeling of nausea but I did stop vomiting. However with those side effects I couldn't take it...migraine with a 17mth old to run around after.......yeah right.