if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Message edited 1/11/2012 10:38:12 PM.

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

I have a known chromosomal issue, and I still didn't do PHD/CGH for my IVF cycle. My doctor felt that if we put back the optimal number of embryos, we would eventually have a "good one" take. Ultimately, that's what happened, and I'm 16 weeks pregnant. However, doing PGD/CGH would have given me a lot of reassurance that everything is okay, as I'm still a nervous wreck, even though my losses were all very early.

We were also paying for IVF OOP and didn't want to spend the extra $5000. We would eventually have done it if I didn't get PG the first or second time around. My doctor also expressed that PGD/CGH can result in getting rid of potentially good embryos that could "correct" themselves in utero, however the genetic counselor didn't really seem to agree with that.

Wishing you the best of luck with whatever you decide!

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

I think pgd/pgs/ cgh testing is a very personal decision. After 6 losses, only 1 out of the four drs. I had consultations with suggested it. I'm also only aware of one loss being a chromosomal problem. My current RE said that we could do it if we wanted but really it would be for more of an informational purpose for him, on how to treat me and really wouldn't increase the chances of me being pregnant because of my other issues. If you are looking into it, I would consider looking at a top rated lab, embryologist, etc. Like with a lot of IVF procedures, there are risks that you may weigh.
For the emotional side of IVF, have you tried therapy? Or looked into a support group? Miscarriage and the suffering it can cause is very sad but serious. A large part of my journey has been healing and accepting all my losses.
HTH!

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

This is my 3rd time doing PGD....it has it benefits and its risks.

I am a carrier of a genetic condition...borderline too. It is something my DH wants to do. I don't really support it too much...after the 2nd time.


The percentages of error are equal to my chance of passing it on. So who knows !FM me if you need to chat.

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Message edited 1/11/2012 10:38:45 PM.

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Posted by Jax430

I have a known chromosomal issue, and I still didn't do PHD/CGH for my IVF cycle. My doctor felt that if we put back the optimal number of embryos, we would eventually have a "good one" take. Ultimately, that's what happened, and I'm 16 weeks pregnant. However, doing PGD/CGH would have given me a lot of reassurance that everything is okay, as I'm still a nervous wreck, even though my losses were all very early.

We were also paying for IVF OOP and didn't want to spend the extra $5000. We would eventually have done it if I didn't get PG the first or second time around. My doctor also expressed that PGD/CGH can result in getting rid of potentially good embryos that could "correct" themselves in utero, however the genetic counselor didn't really seem to agree with that.

Wishing you the best of luck with whatever you decide!

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

is your LH being treated? for me, I had high LH (around 20-25) and i had two early losses. i was treated for blood clotting, immune, and HLA matches. we started treating the LH too, by using ganirelix through the whole stim. at one point my LH was so low that we had to artificially boost it with luveris. however my RE said that it is better to have none and add back then for it to be too high and effect quality.

as far as doing chromosomal testing, i think it depends on how many eggs/embies you produce. if you are a known high responder and can get 20 or so eggs i say do the testing for peace of mind, but know the risk that you may lose perfectly good embies in the process. that is always the risk you take with those kinds of tests. if it were me, i probably wouldn't do it unless it was proven that my losses were chromosomal or if DH and I were carriers of something. because i have a partial HLA match with my husband i asked my RE during my IVF if we could do any testing to make sure the embies would put back did not have the HLA match, and he said the risks far outweighed the benefits although it was possible. so IMO make sure its worth the risk and you have enough embies to work with. it would be a shame to do it without just cause and lose a lot of great embies. JMHO, but good luck with your decision!!!

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Message edited 1/11/2012 10:40:22 PM.

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

How old are you? I did my IVF's at 43 and 44 and opted NOT to do any genetic testing as we already know that the overwhelming majority of my eggs are abnormal at this age. I felt that the risks that one or two possibly normal embryos would be damaged by doing genetic testing was not worth it in my case.

Also..egg quality does not equal genetic issue. It could simply be the stimulation protocol that you are on.

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Message edited 1/11/2012 10:40:55 PM.

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Posted by waterbabies999

Posted by Jax430

I have a known chromosomal issue, and I still didn't do PHD/CGH for my IVF cycle. My doctor felt that if we put back the optimal number of embryos, we would eventually have a "good one" take. Ultimately, that's what happened, and I'm 16 weeks pregnant. However, doing PGD/CGH would have given me a lot of reassurance that everything is okay, as I'm still a nervous wreck, even though my losses were all very early.

We were also paying for IVF OOP and didn't want to spend the extra $5000. We would eventually have done it if I didn't get PG the first or second time around. My doctor also expressed that PGD/CGH can result in getting rid of potentially good embryos that could "correct" themselves in utero, however the genetic counselor didn't really seem to agree with that.

Wishing you the best of luck with whatever you decide!

I totally understand your reasoning, it makes sense. So you had to see a genetic counselor? Was that through your RE?

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Message edited 1/11/2012 10:42:12 PM.

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Posted by waterbabies999

Posted by classc1

I mean that protocol can often lead to egg quality issues. The amount of stims...type...amount of LH...timing...etc. Has he done a repeated loss panel for you? I know that many will only do this with three losses, but you may have clotting or immune issues that are causing the losses too. If you do IVF, they will be able to tell a lot more about the quality of your embryos and whether egg quality might be an issue. Again..a bad protocol can lead to bad egg quality. However, they cannot tell whether or not even a great embryo is abnormal without doing genetic testing. I guess I would be tempted to just do an IVF round without genetic testing at least once and see what happens. You have to decide if you can emotionally take another loss if there is some issue. If you do genetic testing, they can transfer in only normal embryos.

We supposedly corrected my immune issues with intralipids and lovenox. Before my first miscarriage, I did the repeat immune testing while I was still pregnant and all the levels had returned to normal. So for that reason, we dont suspect it is immune related anymore.

I'm going to ask my doctor if he thinks my protocol could have affected the egg quality. I thought I had bad eggs in the first place and by adding in the Ganirelix it corrected it. I'm definitely worried about wasting eggs but from the little that I read, the risk seems low.

Emotionally, of course I dont want another mc, but I'm sure I will deal with whatever life throws at me. I dont see myself jumping off a bridge if I have another (although who really knows!). Sorry, I hope that doesnt sound overly flip. What's $5,000 anyway?!

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Message edited 1/11/2012 10:43:11 PM.

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Have you had genetic counseling? Were you tested for a translocation? That is a very common cause of miscarriages.

Re: if you have any experience or knowlege of pgd or cgh... or even if not, wwyd

Message edited 1/11/2012 10:43:38 PM.