GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL
DYSFUNCTION

Autism is a disorder characterized, in part, by deficits in
communication abilities. Gastrointestinal conditions are common among
individuals with autism, and it may be difficult for some individuals to
communicate that they are experiencing gastrointestinal discomfort. Some
theories of autism speculate that gastrointestinal dysfunction may
impact brain development, while other theories of autism suggest that
the altered nervous system development may affect gastrointestinal
function. In the study, "Distinct Genetic Risk Based on Association of
MET in Families With Co-occurring Autism and Gastrointestinal
Conditions," researchers demonstrate genetic risk may be playing a role
in both the brain and the gut. The scientists found that a functional
genetic variant in a gene called MET is more strongly associated with
autism specifically in those families where an individual had
co-occurring autism and a gastrointestinal condition. Independent
studies have shown that the MET gene product, a receptor tyrosine kinase
protein, functions in both brain development and gastrointestinal
repair. These data suggest that altered MET expression may contribute to
a syndrome that includes autism and co-occurring gastrointestinal
dysfunction.

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

That doesn't surprise me...my cousin who is on the spectrum has Chrohn's Disease.

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

That's very interesting. Can I ask where you got that study from?

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

On my "on-going" research on the topic, I did read about this. This is why some of the diets "may" work in some kids. The alternative medicine of some supplementations of vitamins, specific food to avoid or to eat, make sure the right organisms are in the GI track, etc..

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

Thank you for posting this.

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

Posted by wannabemom

Posted by lipglossjunky73

GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL
DYSFUNCTION

Autism is a disorder characterized, in part, by deficits in
communication abilities. Gastrointestinal conditions are common among
individuals with autism, and it may be difficult for some individuals to
communicate that they are experiencing gastrointestinal discomfort. Some
theories of autism speculate that gastrointestinal dysfunction may
impact brain development, while other theories of autism suggest that
the altered nervous system development may affect gastrointestinal
function. In the study, "Distinct Genetic Risk Based on Association of
MET in Families With Co-occurring Autism and Gastrointestinal
Conditions," researchers demonstrate genetic risk may be playing a role
in both the brain and the gut. The scientists found that a functional
genetic variant in a gene called MET is more strongly associated with
autism specifically in those families where an individual had
co-occurring autism and a gastrointestinal condition. Independent
studies have shown that the MET gene product, a receptor tyrosine kinase
protein, functions in both brain development and gastrointestinal
repair. These data suggest that altered MET expression may contribute to
a syndrome that includes autism and co-occurring gastrointestinal
dysfunction.

this makes a lot of sense..... MET is one of those super-common signal transduction proteins... it signals many things in many different cells... Specifically in development of the brain, it affects hepatocyte growth factor, a signaling molecule that mediates the development of cells responsible for depositing myelin (problems in myelin development is the one consistent thing that histologically identifies an autistic brain.... they have insufficient 'insulation' around their 'wiring')

MET is also involved in a lot of different tissues' development..... so a MET mutation affecting the digestive system is not surprising... it also is involved later in life with the development of various cancers....

problems with cellular signal transduction cascades can be really

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

sorry! I've been writing and editing manuscripts all day... it's hard to flip the gibberish off after a while

abridged version: it makes sense.... MET does a lot of stuff.... it could affect virtually anything in the body... either during development, or later in life (as cancer)

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

Posted by wannabemom

sorry! I've been writing and editing manuscripts all day... it's hard to flip the gibberish off after a while

abridged version: it makes sense.... MET does a lot of stuff.... it could affect virtually anything in the body... either during development, or later in life (as cancer)

Re: GENE VARIANT IS ASSOCIATED WITH BOTH AUTISM AND GASTROINTESTINAL

thanks for posting