Ultra Screening results question
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staceyd
LIF Adult
Member since 8/08 2052 total posts
Name: stacey
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Ultra Screening results question
Just got my results and they said they were normal... I was just wondering, what is a normal number? They gave me mine but I don't remember the numbers that she told me were borderline and which were normal.. anyone know? THANKS
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Posted 10/10/08 1:38 PM |
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MrsRbk
<3 <3 <3 <3
Member since 1/06 19197 total posts
Name: Michelle
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Re: Ultra Screening results question
Normal I think is different for everyone. Based on my age, normal for me was a lower number than what might be normal for someone younger than me. KWIM?
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Posted 10/10/08 1:40 PM |
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NinaLemon
It's a boy!!!
Member since 10/07 6453 total posts
Name: Jeannine
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Re: Ultra Screening results question
Here is some info I found:
Mother's Age Incidence of Down Syndrome Under 30 - Less than 1 in 1,000 30 - 1 in 900 35 - 1 in 400 36 - 1 in 300 37 - 1 in 230 38 - 1 in 180 39 - 1 in 135 40 - 1 in 105 42 - 1 in 60 44 - 1 in 35 46 - 1 in 20 48 - 1 in 16 49 - 1 in 12
Measurements for Down Syndrome Earlier parameters used included the actual to expected FL ratio, the BPD/FL ratio. More recently the nuchal translucency thickness is used in detecting Down syndrome fetuses.
In Down syndrome both the femur and the humerus tend to be shortened.
The expected FL = -9.645 + 0.9338 x BPD
If the ratio is below 0.84 the likelihood of Down syndrome is higher.
The BPD/FL ratio should be established for each individual population, and it’s value varies with gestation. The mean +1.5 SD is usually used as the cutoff level.
_____________________________
GA (weeks) --- BPD/FL ratio#
15 --------------------- 1.93
16 --------------------- 1.93
17 --------------------- 1.76
18 --------------------- 1.74
19 --------------------- 1.69
20 --------------------- 1.58
21 --------------------- 1.54
22 --------------------- 1.47
______________________________
Positive predictive value 1/294 for the general population ( normally 1/1000 ) and 1/112 for maternal age over 35 (normally 1/270).
The BPD/FL ratio and the nuchal skin fold thickness can be used in conjunction with the maternal age incidence to arrive at a new probability for the occurrence of Down syndrome in a particular fetus.
The nuchal translucency thickness is the thickness of the skin fold behind the nape of the neck. In chromosomal abnormalities this may be thickened due to venous or lymphatic engorgement. In the measurement of the nuchal skin fold thickness, critical landmarks should include the cavum septum pellucidum, the cerebral peduncles and the cerebellar hemispheres. Calipers are placed from the outer skull table to the outer skin surface.
Percentage of Down syndrome fetuses with nuchal fold >6 mm after 16 weeks vary from 69% (Benacerraf 1991) to as low as 3.8% (Grandjean 1995) in different reports. A mean value of about 50% can be obtained from different reports.
The Percentage of Down syndrome with Nuchal folds equal or greater than 3mm before 14 weeks ranges from 1.5% (Rodeck 1995) to 18% (Nicolaides 1994) and 45% (Salvesen 1995) in different reports
The Nicolaides group, basing on their findings in 1015 fetuses at 10-13 weeks with nuchal fold greater than 3mm arrived at the following risks estimates:
3mm ------ 3 times
4mm ------ 18 times
5mm ------ 28 times
6mm ------ 36 times the incidence by maternal age.
The incidence of Down syndrome at the age of 35 is around 1 out of 270. If the fetus has a nuchal skin fold of 6mm the risk of Down syndrome would have become 270/36 or 1 out of 7.5.
In general the combination of beta-HCG and nuchal translucency thickness can increase the detection rate of Down syndrome fetuses by almost 3 folds compared to maternal age alone.
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Posted 10/10/08 1:51 PM |
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Katie111806
Team Pink!
Member since 12/06 5349 total posts
Name: Katie
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Re: Ultra Screening results question
"Normal" definitely varies by age, ethnicity, weight, etc. In my doctor's practice, they recommend/suggest further more invasive testing (ie amnio) if results are worse than 1:270.
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Posted 10/10/08 3:43 PM |
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staceyd
LIF Adult
Member since 8/08 2052 total posts
Name: stacey
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Re: Ultra Screening results question
Thank you!!! I know everything is normal according to the dr.. just checking up for any insight anyone might have!
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Posted 10/10/08 4:15 PM |
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